ERBB2 and neoplasm: A recent study revealed significant homology between human and canine epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2) and indicated that both molecules contain highly conserved epitopes for the therapeutic antibodies cetuximab and trastuzumab, with targeting inducing the tumoristatic effects of canine tumor cells overexpressing EGFR or HER-2 [18].