ERBB2 and neoplasm: Trastuzumab and cetuximab induced significant ADCC responses of canine NK cells in tumor cells expressing HER-2 and/or EGFR, regardless of the degree of expression (Fig. 5b), suggesting that FcγRIII expressed on the surface of cultured canine NK cells can bind to the Fc constant regions of the human antibodies as reported by Bergeron et al. [35].