In the CAD group, SREBP-1 showed positive associations with HDL (r = 0.171, p = 0.011), Apo-A1(r = 0.145, p = 0.033) and CysC (r = 0.150, p = 0.027), GSP (r = 0.229, p = 0.001) and negative associations with CK-MB (r = − 0.201, p = 0.003), LDH (r = − 0.146, p = 0.031) and hs-CRP (r = − 0.284, p < 0.001) in non-CAD controls. Here, SREBF1 is linked to coronary artery disorder.