As summarized in Table 3, odds ratios (ORs) were significant after adjustment for age, gender (OR = 0.77, 95% confidence interval [CI] = 0.64~0.93, p = 0.006), although these associations were abolished when history of hyperlipidemia, diabetes and hypertension was included as covariates (OR = 0.84, 95%CI = 0.64~1.11, p = 0.226), the decreased SREBP-1 expression was still a significant risk factor for CAD after adding Statins medication as a covariate (OR = 0.48, 95% CI 0.30~0.76, p = 0.002). The gene discussed is SREBF1; the disease is hyperlipidemia.