Sera’s patient from endemic flaviviruses countries of Colombia and the Dominic Republic were analyzed, the assay demonstrated IgG and IgA antibodies against ZIKV non-structural protein 1 (NS1) antigen were specific to ZIKV infection, and IgG avidity shown acute ZIKV infection and past DENV-2 infection [5]. This evidence concerns the gene CD79A and Zika virus infectious disease.