The predominant accumulation of CD4+ Tregs over T helper cells type 1 (Th1) in the aortas of Atg16l1 cKO Ldlr−/− mice was associated with a significant reduction of atherosclerosis development at the level of the aortic root (Figure 3D) and in the en face thoracic aorta (Figure 3E). Here, LDLR is linked to atherosclerosis.