CD4 and atherosclerosis: To further understand how Atg16l1 deficiency in CD11b+ but not CD8α+ DCs favors the expansion of CD4+ Tregs upon HFD feeding in Ldlr−/− mice and prevents atherosclerosis, we purified splenic DCs (after bone marrow transplantation and 8 weeks of HFD) and analyzed their transcriptomic signature by RNA sequencing (Figure 6A and Online Table I).