CYP11A1 and infection: Similar to NCLAH, it is now emerging that partial loss of function of CYP11A1 (encoding P450scc) also presents with a predominant adrenal phenotype, affecting glucocorticoids and sometimes mineralocorticoid synthesis.62, 63 Patients can present at different ages throughout childhood, often with hyperpigmentation, hypoglycaemia or prolonged illness with infections.