Severe disruption of STAR or P450scc/CYP11A1 causes a block in all aspects of adrenal and gonadal steroid synthesis.56, 57, 58 For STAR defects this is known as congenital lipoid adrenal hyperplasia (CLAH).56 Individuals with these conditions tend to present in the first month of life with salt‐losing adrenal insufficiency and cortisol insufficiency. Here, STAR is linked to congenital adrenal hyperplasia.