CDKN1C and Beckwith-Wiedemann syndrome: Interestingly, loss‐of‐function of this growth repressor, CDKN1C, is found in approximately 10% of patients with Beckwith‐Wiedemann syndrome (BWS), an “overgrowth” syndrome.41, 45 Children with BWS are at risk of adrenal tumours highlighting how developmental hypoplasia and cancer can sometimes be at opposite ends of a molecular spectrum.