Expression of ImpL2 was shown to be regulated by Hif1α (Li et al., 2013), and as ImpL2 was previously identified as a mediator of cancer-induced loss of energy reserves in flies due to its anti-insulin role (Kwon et al., 2015; Figueroa-Clarevega and Bilder, 2015), it could represent another link between AG in macrophages and changes in systemic metabolism that ensure sufficient supply of energy resources. The gene discussed is INS; the disease is cancer.