MAPT and Alzheimer disease: Considerable evidence shows that upregulation and accumulation of a small peptide, called amyloid‐β (Aβ), are primary pathogenic events of AD,1, 2, 3 which drive the other critical components involved in AD pathologies, including tau protein hyperphosphorylation and neuroinflammation.4, 5, 6, 7, 8, 9 The etiology of AD is complex and the mechanistic elucidation of AD pathogenesis remains inconclusive.