Deletion of this enhancer using CRISPR/CAS9 genome editing produced mice that expressed less hippocampal CNR1 mRNA, that drank less alcohol, had altered levels of anxiety‐like behavior and had a blunted response to cannabinoid‐1 receptor agonism (Hay, Cowie et al., 2019; Hay, McEwan et al., 2019). This evidence concerns the gene CNR1 and Anxiety.