52 Two additional PKC activators aplysiatoxin and debromoaplysiatoxin were identified in a screen of natural compounds purified from marine invertebrates and microorganisms (Figure 4, Tables 1 and 3).47 These compounds are produced by blue‐green algae, and were initially identified as agents with proinflammatory and tumor‐promoting activities.140 Similar to phorbol esters, these compounds bind the C1 regulatory domain of PKC which facilitates interaction with the cell membrane phospholipid bilayer causing activation of the enzyme.141, 142, 143. Here, PRRT2 is linked to neoplasm.