Others have reported the use of Raman and attenuated total reflectance-Fourier transform infrared spectroscopy spectroscopy to distinguish IDH-mutant versus IDH-wild-type but have used snap frozen sections before spectroscopy, which still requires laboratory-based sample preparation.36,37 These vibrational spectroscopy studies have not attempted to distinguish oligodendrogliomas as a separate group, which is essential for clinical decision-making. The gene discussed is IDH2; the disease is oligodendroglioma.