Alongside these studies, it will also be crucial to investigate the effect of the host on tau oligomer formation; for factors like the genetic makeup such as APOE (Nathoo et al., 2003) and TREM2 (Bemiller et al., 2017; Leyns et al., 2017) alleles also affect tau oligomers and thus contribute to determining the risk for neurodegeneration and late-life dementia (Little et al., 2014). This evidence concerns the gene APOE and dementia.