Human HCC samples with increased SIRT1 expression and high cytoplasmic MRPS5 levels presented more CSCs and were associated with high metastases rates, cancerous embolization, increased tumor size, and decreased survival compared to patients whose HCC biopsies showcased low cellular SIRT1 expression and high nuclear MRPS5 levels. The gene discussed is MRPS5; the disease is hepatocellular carcinoma.