Further, for the management of pancreatic cancer and its early detection Eissa et al. analyzed the methylation of ADAMTS1 and BNC1 in cfDNA using qMSP, which exhibited a sensitivity of 94.8% and specificity of 91.6% with a AUC of 0.95 reflecting diagnostic potential of this blood based two-gene panel in detection of pancreatic cancer at an early stage (Eissa et al., 2019). This evidence concerns the gene ADAMTS1 and familial pancreatic carcinoma.