Using a high–throughput approach to screen genes that showed highest differential methylation between ovarian cancer and normal tissue, Melnikov et al. identified 10 genes to be informative in tissue samples which include: BRCA1, EP300, NR3C1, MLH1, DNAJC15, CDKN1C, TP73, PGR, THBS1, and TMS1. This evidence concerns the gene BRCA1 and ovarian cancer.