Recently using genome-wide methylation data analysis, five-methylation signature (SLC39A14, PREX2, KCNIP2, CORO6, and EFNB1) were reported as novel independent prognostic biomarker for patients with ovarian serous cystadenocarcinoma, which significantly associated with OS of patients. The gene discussed is KCNIP2; the disease is ovarian serous cystadenocarcinoma.