SERPINB5 and cancer: Promoter hypomethylation induced upregulation of other cancer-associated genes in ovarian cancer includes maspin (SERPINB5) (Rose et al., 2006), MCJ (Strathdee et al., 2004, 2005), and SNCG (synucelin-γ) (Gupta et al., 2003; Czekierdowski et al., 2006b), which encodes an activator of the MAPK and Elk-1 signaling cascades.