In ovarian cancer, a large number of tumor suppressor genes have been identified to be silenced by promoter hypermethylation and downregulated includes DAPK, LOT1, TMS1/ASC, and PAR4 (pro-apoptotic function and cell cycle regulation), p16, SPARC, ANGPTL2, and CTGF (tumor suppressor activity), ICAM-1 and CDH1 (cell adhesion), PEG31 (role in imprinting) and many others (Tables 4, 5). The gene discussed is SPARC; the disease is ovarian cancer.