Early Loss of E3 ubiquitin ligase RNF20 and histone H2B monoubiquitylation (H2Bub1) has been reported to drive ovarian tumorigenesis by altering chromatin accessibility and thereby activating immune signaling pathways (IL6), and this loss has been defined by majority of high grade serous ovarian carcinomas tumors (Hooda et al., 2019). Here, RNF20 is linked to ovarian serous carcinoma.