Furthermore, the TP53 mutations, I251M and R175G, have been detected in the ctDNA of individual pancreatic cancer patients pre-surgery, and the mutations G293E, M340Cfs*5, S362Afs*8, and T211I have been detected in individual patients who developed metastasis after resection of the primary tumor (82). Here, TP53 is linked to pancreatic neoplasm.