Some aspects of the role of SIRT1 in cell fate control in osteosaroma (28) and mesothelioma (29, 30) have been described as well as increased response to chemotherapy upon inhibition of autophagy in mesothelioma (31) but the role of the other sirtuin family members in autophagy and response to drug treatment in osteosarcoma and mesothelioma has not been clearly elucidated. Here, SIRT1 is linked to osteosarcoma.