In a previous study, after quantifying LOX-1 expression among several CRC cell lines, we focused our attention on two cell lines overexpressing LOX-1, HCT8 (non-metastatic), and DLD-1 (metastatic), in which we stably down modulated LOX-1 expression by RNAi (29). This evidence concerns the gene OLR1 and colorectal carcinoma.