PTEN and neoplasm: For example, conditional knockout of miR-31 was shown to promote the development of colitis-associated cancers (52); miR-193b exhibited a tumor suppressive role in human esophageal squamous cell cancers via targeting KRAS (48); miR-200c-3p suppressed the proliferative and invasive abilities of nephroblastoma cells via targeting FRS2 (49); miR-4286 and miR-513b each promoted cell proliferation and migration via targeting Pten and HMGB3, respectively, in non-small cell lung cancer (53, 54) (Table 1).