For example, the lncRNA H19 can function as a miRNA reservoir of miR-675 that suppresses cell growth (37) and as a miRNA sponge of let-7a that up-regulates cyclin D1 expression (146); the lncRNA XIST interacts with histone methyltransferase at the transcriptional level in regulating chromosome dosage compensation (46), and sponges miR-34a to promote colon cancer progression at the post-translational level (130). The gene discussed is PRDM9; the disease is malignant colon neoplasm.