TargomiRs are minicells carrying miR-16-based mimic miRNAs targeting EGFR, which counteract recessed expression of miR-15 and miR-16 family miRNAs in malignant pleural mesothelioma by design; and a phase I, open-label, dose-escalation study assessing the safety and activity of TargomiRs was conducted in patients carrying malignant pleural mesothelioma, with positive results being reported (120) (Table 2, Supplementary Table 1). The gene discussed is EGFR; the disease is malignant pleural mesothelioma.