For instance, the lncRNA CCAT1 could elevate the expression of target genes Hmga2 and c-Myc in hepatocellular carcinoma via sponging their negative regulator let-7 (33); the lncRNA NEAT1 represses glioma progression and reduces its malignancy through sponging miR-107 and inhibiting CDK14 (41); the lncRNA SPRY4-IT1 promotes EMT of cervical cancer by sponging miR-101-3p (43); and the lncRNA FER1L4 functions as a sponge of miR-372 that targets E2F1 to regulate cell cycle progression in glioma cells (35) (Table 1). This evidence concerns the gene SPRY4 and central nervous system cancer.