For example, lncRNA aHIF is an antisense RNA (aRNA) overexpressed in human renal cancer with drugging potential; LINK-A overexpression was observed in breast and lung cancer patients that had developed resistance to AKT inhibitors, providing the rational for targeting LINK-A, either alone or in combination with AKT inhibitors, in the treatment of such cancers (112). This evidence concerns the gene AKT1 and lung carcinoma.