BDNF and ovarian carcinoma: Considering that the activation of ERK signaling pathway by BDNF/TRKB was associated with an increase of VEGF expression in osteoblasts (93), and given that TRKB can activate PI3K and ERK signaling pathways which regulate VEGF expression in several models (119–121), it is plausible that the VEGF expression could be increased by TRKB in cervical cancer, similarly to ovarian cancer.