In addition, NGF/TRKA stimulates cellular proliferation of EOC cells, by the activation of MAPK/ERK and AKT pathways, increasing Bcl2/Bax ratio and c-Myc (104), indicating the importance of NGF/ TRKA in EOC progression and suggesting that they could be considered as a potential tumor markers. The gene discussed is NTRK1; the disease is neoplasm.