After choosing the h.all.v6.2.symbols.gmt gene set, there were two common enriched pathways, hallmark G2/M checkpoint and hallmark spermatogenesis, in the meta-GEO cohort and the TCGA cohort of the high CELSR3 mRNA expression phenotype (Fig. 5E; Table 4), and one common enriched pathway, hallmark DNA repair, in the meta-GEO cohort and the HCC cell line cohort of the high CELSR3 mRNA expression phenotype (Fig. 5G; Table 4). The gene discussed is CELSR3; the disease is hepatocellular carcinoma.