CELSR3 and hepatocellular carcinoma: GO somatic diversification of immune receptors, GO endonuclease activity, GO DNA repair complex and GO somatic cell DNA recombination were differentially enriched in both tissue specimens and the cell line cohort; these may be the pathways in which CELSR3 participates in the regulatory mechanism of HCC.Therefore, CELSR3 might be a valuable biomarker for HCC patients.