In the TCGA and GEO tissue samples, biocarta G1 pathway, ATR and BRCA pathway, E2F targets, hallmark G2/M checkpoint and hallmark spermatogenesis were differentially enriched in the CELSR3 high expression phenotype, while they were not differentially enriched in the CELSR3 high expression phenotype of the HCC cell line cohort. Here, ATR is linked to hepatocellular carcinoma.