After choosing the c5.all.v6.2.symbols.gmt gene set, four pathways, GO somatic diversification of immune receptors, GO endonuclease activity, GO DNA repair complex and GO somatic cell DNA recombination, were differentially enriched in the meta-GEO cohort, the HCC cell line cohort and the TCGA cohort of the high CELSR3 mRNA expression phenotype (Figs. 5C, 5F, 5H; Table 5). Here, CELSR3 is linked to hepatocellular carcinoma.