Bettayeb et al. (2016) highlighted 12 SNPs including rs7531886, rs12033011, rs72868007, rs73022058, rs3132828, rs498872, rs34280607, rs61614746, rs757352, rs9898218, rs7216504, and rs11650615 in COPI genes COPA, COPB1, COPD/IFT46, COPD/PHLDB1, COPZ1, COPZ2, and COPZ2/NFE2L1 to be significantly associated with increased AD risk. The gene discussed is PHLDB1; the disease is Alzheimer disease.