By means of TWAS, we retrieved significant data on expression quantitative trait locus (eQTL) for SQSTM1, finding negative associations (Chi2 value equal to -3) between AD trait and two tissue models, Brain Prefrontal Cortex and Thyroid Carcinoma, thus suggesting a link between the gene expression variation and the genotypes, deserving further investigation with respect to the inverse relationship between cancer and AD. The gene discussed is SQSTM1; the disease is Alzheimer disease.