Notably, we found two genes displaying a negative association between Alzheimer’s Disease (including proxy) trait and Lung Squamous Cell Carcinoma model with Chi2 value of -18.3 (APOE) and -22.7 (APOC1) (see TWAS Trait association table at twas-hub.org/genes/APOE/and twas-hub.org/genes/APOC1/). The gene discussed is APOC1; the disease is early-onset autosomal dominant Alzheimer disease.