MiR-34a-5p targets in Module 1 include BECN1. The elevated miR-34a-5p levels marking AD condition are expected to reduce the cellular amount of Beclin1 and hence to affect the efficiency of the autophagy machinery in clearing protein aggregates, providing a link between miR-34a dysregulation and β-amyloid pathology in AD. Here, BECN1 is linked to Alzheimer disease.