ICOS and melanoma: Besides, in meta-analysis of Oncomine, THBS2 (Median rank 1,088, P < 0.001) (Figures S8A, B), ICOS (Median rank 1,008, COPA = 1.854) (Figures S8C, D), CXCL13 (Median rank 536.5, COPA = 30.145) (Figures S8E, F), BCL6 (Median rank 434.5, COPA = 2.016) (Figures S8G, H), MME (median rank 221.0, COPA = 8.940) (Figures S8I, J), and PDCD1 (median rank 7,680, P = 0.350) (Figures S8C, D) all showed significant results in multiple melanoma–related studies except PDCD1.