THBS2 and cancer: Moreover, the overexpression of THBS2 had been demonstrated to be positively correlated with node metastasis and over survival in many types of cancer, including colorectal adenocarcinoma, myxoid liposarcoma, prostate cancer, and gastric cancer (Kim et al., 2010; Slavin et al., 2014; Chang et al., 2016; Lin et al., 2016; Nezu et al., 2016; Zhuo et al., 2016; Qian et al., 2017; Wei et al., 2017).