DDB2 and chromosome-type aberration frequency: DDB1 was initially identified as a damaged DNA binding protein that heterodimerizes with two DWD-containing proteins, Damage-specific DNA Binding protein 2 (DDB2) and Cockayne Syndrome A (CSA), that control different NER pathways, global genome repair (GGR) and transcription-coupled repair (TCR), respectively (Lee and Zhou, 2007; Shuck et al., 2008).