The differential metabolites among five truffle species covered a total of 110 pathways or metabolisms, including vitamin digestion and absorption, vitamin B6 metabolism, serotonergic synapse, drug metabolism-cytochrome P450, amino sugar and nucleotide sugar metabolism, ABC transporters, sulfur metabolism, microbial metabolism in diverse environments, biosynthesis of secondary metabolites, central carbon metabolism in cancer (Supplementary Table S1), and the 20 most enriched pathway terms are shown in the KEGG enrichment bubble diagrams (Figure 6). The gene discussed is ABCG2; the disease is cancer.