The results of this study showed that the increase in the CD8+ and CD4+ T cell population in the intestinal mucosa of Cy immunosuppressed mice and orally infected with E. intestinalis, in association with the presence of pro-inflammatory cytokines, controlled the infection by the opportunistic fungus, although reduction of cellular populations at immune sites has been observed, confirming a state of immunosuppression, reinforcing that the selective effect of Cy should be better understood. This evidence concerns the gene CD8A and infection.