Neurofilament light protein (NFL), a cytoskeletal polypeptide of the axon (1), and chitinase 3-like 1 (CHI3L1- also known as YKL40 or gp39), a glycoprotein secreted by activated glia in the central nervous system (CNS) (2), have both shown to be biomarkers of axonal destruction, and inflammation in multiple sclerosis (MS), respectively. This evidence concerns the gene NEFL and multiple sclerosis.