Most of them, however, cannot trigger proper and effective immune response (Buonaguro et al., 2010), including the tumor associated mucin-type O-glycans Tn, sTn, and T antigen (Fu et al., 2016), which are almost exclusively found in cancer cells and have been widely employed in cancer diagnosis and prognosis prediction (Kudelka et al., 2015). Here, MUC5AC is linked to cancer.