Moreover, we found that matrine could inhibit the expression of c-Myc and HK2, which are a transcription regulator reprogramming tumor cell metabolism and a glycolytic rate-limiting enzyme catalyzing the phosphorylation of glucose to produce glucose-6-phosphate, respectively (Roberts and Miyamoto, 2015; Dejure and Eilers, 2017). The gene discussed is HK2; the disease is neoplasm.