For instance, impairment of glycolysis by either pyruvate kinase M2 (PKM2) or lactate dehydrogenase-A (LDHA) deletion could markedly delay leukemia initiation in both CML and acute myeloid leukemia (AML) models (Wang et al., 2014). Here, LDHA is linked to chronic myelogenous leukemia, BCR-ABL1 positive.