APP and Alzheimer disease: The decrease of spontaneous alternation in the TM has also been observed in other transgenic models of AD such as Tg2576 (Lalonde et al., 2003) and APP/PS1 (Tempier et al., 2013) mice, in animal models for schizophrenia as STOP-null mice (Delotterie et al., 2010), or pharmacological models by selective blockade of dopamine D1 and D2 receptors in the pre-limbic region of the prefrontal cortex (Rinaldi et al., 2007).