APP and Alzheimer disease: In accordance with previous data (Lee et al., 2014; Guo et al., 2015), here we show that an impaired autophagic flux is present, as indicated by an increase of LC3 II/LC3 I and p62 level in vivo in model mice, whereas with the in vitro study, LC3 II/LC3 I decreased but the level of p62 increased in APP/PS1 double transgenic HEK293 cells, indicating that both the formation and degradation of autophagosome are obstructed in AD.