INS and myeloid sarcoma: Although oral butyrate supplement can improve HFD-induced MS and coronary artery disease in mice via histone deacetylases (Gao et al., 2009), a recent research indicated that oral butyrate treatment exerts a beneficial effect on glucose metabolism in healthy males instead of MS patients (Bouter et al., 2018), thus suggesting that the effects and molecular mechanism of butyrate in glucose metabolism and insulin resistance need to be confirmed further.