Previous studies have reported that BASR-CHMs promote angiogenesis by upregulating vascular endothelial growth factor (VEGF) gene in the ischemic model (Xin et al., 2018; Zheng et al., 2018; Shi et al., 2019) and inhibit angiogenesis mainly by downregulating VEGF and decreasing MMP9 expression in tumor tissues (Zeng et al., 2018). Here, MMP9 is linked to neoplasm.