Likewise, sAPPα could rescue LTP in acute hippocampal slices from mice lacking both APP and its family homolog APP-like protein 2 (APLP2) (Hick et al., 2015), and prevented memory deficits after lentiviral overexpression in the APPswe/PS1dE9 AD mouse model (Tan et al., 2018). Here, APP is linked to Alzheimer disease.