RELN and early-onset autosomal dominant Alzheimer disease: Genetic studies have demonstrated an association between the RELN locus and autism spectrum disorder (ASD; Wang et al., 2014), schizophrenia (Ovadia and Shifman, 2011; Li et al., 2015), bipolar disorder (Ovadia and Shifman, 2011), and Alzheimer’s disease (Bufill et al., 2013).