Some studies have reported increased anxiety, impaired executive function, motor impulsivity, abnormal prepulse inhibition, decreased contextual fear conditioning and associative learning impairments in Reln+/– mice (Tueting et al., 1999; Tremolizzo et al., 2002; Krueger et al., 2006; Qiu et al., 2006) whereas other groups report that Reln+/– display normal locomotor activity, prepulse inhibition, anxiety, coordination, social behavior, spatial learning and transitions in the light–dark test, a measure of anxiety (Podhorna and Didriksen, 2004; Qiu et al., 2006). Here, RELN is linked to Anxiety.