CX3CR1 and brain ischemia: Since it was demonstrated that during the progression of cerebral ischemia microglia phenotype changes from anti- to pro-inflammatory (Fumagalli et al., 2015; Ma et al., 2017) and microglia express CX3CR1, we investigated whether the neuroprotective effect of CX3CL1 in ischemia is due to its ability to change the phenotype of microglia.