Moreover, it induces a metabolic switch with an increased expression of genes related to the oxidative pathway and a reduction in those related to glycolytic one, which is the metabolic state associated to the pro-inflammatory phenotype for energy production, suggesting that CX3CL1 protects against cerebral ischemia injury modulating the activation state of microglia and its metabolism in order to restrain inflammation and activate a neuroprotective response against the ischemic insult. This evidence concerns the gene CX3CL1 and brain ischemia.