With the increasing disappearance of the DA terminals and extracellular DA levels, especially in the striatum of Parkinson’s disease, a major reorganization of the multiple A2AR and mGluR5 complexes at the pre and postsynaptic level of the cortico-striatal glutamate synapses will take place, with marked disturbances in motor function. The gene discussed is ADORA2A; the disease is Parkinson disease.