Deletions, duplications, and various point mutations of the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene that encodes neuronal excitatory postsynaptic core scaffolds are causally associated with numerous brain disorders, including autism spectrum disorders, bipolar disorder, intellectual disability, and schizophrenia (Grabrucker et al., 2011; Monteiro and Feng, 2017). The gene discussed is SHANK3; the disease is Intellectual disability.