TMBIM4 and amyotrophic lateral sclerosis: Several autosomal recessive mutations in S1R are linked to ALS (Luty et al., 2010; Al-Saif et al., 2011; Kim et al., 2014; Li et al., 2015; Ullah et al., 2015; Gregianin et al., 2016; Horga et al., 2016; Watanabe et al., 2016; Wong et al., 2016), but how these mutations impact S1R’s role in synaptic stability has not been previously investigated.