Further analysis of the PLS3 interactome uncovered several putative PLS3 interacting partners, which are associated with various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), Charcot-Marie-Tooth disease (CMT), and ARCA (Hosseinibarkooie, 2016). Here, PLS3 is linked to neurodegenerative disease.