Changes in the RPE junctional architecture have been previously characterized in other models of retinal degeneration (Campbell et al., 2006; Chrenek et al., 2012), nonetheless, to our knowledge, this is the first report of a decrease of ZO-1 immunostaining in an RP model, suggesting an increase of BRB permeability. The gene discussed is TJP1; the disease is retinal degeneration.