CD8A and neoplasm: Notably, however, there is also evidence that WNT signalling might enhance the generation of self-renewing, multipotent CD8+ memory stem cells, which might be important for the creation and maintenance of a potent anti-tumour immune response.60 These data suggest that WNT signalling might also confer a beneficial role in effector function and survival of mature T cells.61 Therefore, the potential effects of WNT signalling should be further investigated in the context of immune checkpoint responsiveness in MSI-H/MMR-D CRC patients.