A proteogenomic study investigating the metabolism of MSI-H/MMR-D CRC samples identified an inverse association between glycolysis and CD8+ T-cell infiltration, suggesting that hypoxic tumours with increased anaerobic glucose catabolism might generate excessive lactate, which is a negative regulator of CD8+ T cells.34 These data indicate that tumour metabolism, perhaps also tumour volume, might have an important impact on the fate of the immune response in MSI-H/MMR-D CRC patients.35 This evidence concerns the gene CD8A and colorectal carcinoma.