Ki-67 expression, an indicator of proliferation of immune cells and tumour cells, did not differ between the IM-PD/SU-treated and IM-PD groups; however, there was a significant increase in the expression of immune checkpoint molecules on CD3+ T cells and PD-L1 expression of DOG-1+ tumour cells in the IM-PD/SU-treated group compared to the IM-PD group. The gene discussed is MKI67; the disease is neoplasm.