Caveolin-1 (a major component of caveolae) and caveolae have previously been shown to polarize at the rear of migrating endothelial cells, fibroblasts, and neurons (Beardsley et al., 2005, Lentini et al., 2008, Parat et al., 2003), although in metastatic cancer cells, this is not always observed (Urra et al., 2012). The gene discussed is CAV1; the disease is metastatic malignant neoplasm.