Copy number and single nucleotidevariations in the TUSC3 have been associated with theautosomal recessive syndromic or non-syndromic ID.Previous clinical studies have presented moderate tosevere ID, as a common feature in all of these patients.Additionally, speech problems, minor dysmorphicfeatures and developmental delay was also observed inmost of these patients (Table 1). The gene discussed is TUSC3; the disease is Global developmental delay.