The regulatory role ofaryl hydrocarbon receptor (AhR) and its endogenous ligand, 6-formylindolo[3,2-b]carbazole (FICZ) on the expressionof tumor suppressor miRNAs, miR-22, miR-515-5p and miR-124-3p, as well as their association with the estrogenreceptor alpha (ERα) were the aims of this study. Here, AHR is linked to neoplasm.