We also observed significantincrease in the percentage of NKG2D+ NK cells in thepresence of plasma-derived exosome of responsiveDLBCL patients plus IL-2/IL-15 in comparison withthe absence of exosomes in responsive DLBCL patients(P=0.02) and healthy donors (P=0.003). This evidence concerns the gene IL15 and diffuse large B-cell lymphoma.