We investigated whether plasma-derived exosomes ofresponsive or refractory/relapsed patients with DLBCLplays role in the proliferation of NK cells (Fig .5).Proliferation rate of NK cells from healthy donors wasmore than responsive DLBCL patients and refractory/relapsed DLBCL patients in the absence of exosomesor in presence of IL-2/IL-15 as well as plasma-derivedexosome of DLBCL patients (P<0.001). This evidence concerns the gene IL2 and diffuse large B-cell lymphoma.