In addition, IFN-γ concentration in the culturesupernatant of NK cells from refractory/relapsed DLBCLpatients was lower than the responsive DLBCL patientsin the presence of IL-2/IL-15, plasma-derived exosomeof responsive patients and refractory/relapsed patients(P=0.002, P=0.001 and P=0.002, respectively). Here, IL15 is linked to diffuse large B-cell lymphoma.