No significant difference was found in the percentage ofCD69+ or NKG2D+ NK cells in the presence of plasma-derived exosome of DLBCL patients in each group.Contrarily, some studies demonstrated that NKG2Dexpression is down-regulated by micro-vesicles orexosomes, associated with TGF-ß1 and IL-10 and/orexosomes bearing NKG2D ligands. The gene discussed is IL10; the disease is diffuse large B-cell lymphoma.