Our findings showed that the percentage of CD16+ NK cellsfrom healthy donors was more than refractory/relapsed DLBCLpatients in the absence of exosomes or in the presence of IL-2/IL-15, plasma-derived exosome of responsive DLBCL patientsand plasma-derived exosome of responsive DLBCL patientsplus IL-2/IL-15 (P=0.0001, P=0.0001, P=0.008 and P=0.001,respectively). The gene discussed is IL15; the disease is diffuse large B-cell lymphoma.