We also observedsignificantly increased CD69+ NK cell percentage in thepresence plasma-derived exosome of refractory/relapsedDLBCL patients plus IL-2/IL-15 in comparison with theabsence of exosomes in responsive DLBCL patients andhealthy donors (P=0.014 and P=0.005, respectively, LSDPost-Hoc). This evidence concerns the gene CD69 and diffuse large B-cell lymphoma.