There wassignificant increase in percentage of NKG2D+ NK cells inthe presence of IL-2/IL-15 in comparison with the absenceof exosomes in refractory/relapsed DLBCL patients(P=0.05), responsive DLBCL patients (P=0.0001) andhealthy donors (P=0.014). This evidence concerns the gene IL2 and diffuse large B-cell lymphoma.