Taken together, the present study suggests thatevaluation of cytosolic phospholipase A2 deltaconcentration, alone or in consolidation with otherconventional markers, may provide critical knowledgefor the early noninvasive disclosure of HCC.Moreover, cytosolic phospholipase A2 delta might alsobe served as a potential target to find out the status andprogression of liver cancer. Here, PLA2G4D is linked to liver cancer.