CD86 and Sepsis: Loss of HLA‐DR surface expression is a well‐known phenomenon in sepsis, as surrogate marker of immunosuppression and predictor of poor outcomes.6, 7, 8, 9 Here, monocytes in sepsis patients expressed lower levels of HLA‐DR and CD86 during the first 36 hr of presenting with acute illness, compared with healthy controls (Fig. 3), suggesting functional defects in those patients.