In PBMC cultures, zoledronate treatment led to an upregulation of HLA‐DR as well as CD40 and CD64 on sepsis monocytes, which at least in the case of HLA‐DR and CD40 could be inhibited by the addition of neutralising reagents against IFN‐γ and TNF‐α (Fig. 4). Here, IFNG is linked to Sepsis.