Our study highlighted a peculiar pattern of a lower histone gene expression and defined a three-HIST1 mRNA signature, containing three histone genes (HIST1H1D, HIST1H2BH, and HIST1H2BG) that are directly affected by the H3K27me3 enrichment and can predict survival on CN-AML patients. The gene discussed is H1-3; the disease is acute myeloid leukemia.