In the same line, our study suggests that epigenetic modifications induced by H1-3 targeting could prime AML cells toward differentiation, revealed by ATRA-sensitivity, which may explains the more mature phenotype found in H3K27me3 HIST1high leukemia and suggests that ATRA could be an efficient differentiating agent in AML with low H1-3 expression. The gene discussed is H1-3; the disease is leukemia.