EGFR and non-small cell lung carcinoma: In the past few decades, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, erlotinib and icotinib, have been the most commonly used as a targeted therapy for patients with different types of EGFR-mutated NSCLC, which are believed to be the cornerstone of combined treatment with other drugs.